Role of IL-1 in renal ischemic reperfusion injury.

M Haq, J Norman, SR Saba, G Ramirez… - Journal of the American …, 1998 - journals.lww.com
Abstract Interleukin-1 (IL-1) is a central component of many acute inflammatory processes.
Blocking IL-1 receptor (IL-1R) with IL-1R antagonist (IL-1Ra) has attenuated ischemic
reperfusion injury in brain, heart, and liver models. However, the role of IL-1 in renal
ischemic reperfusion injury (IRI) is not known. Therefore, the role of IL-1 in renal IRI was
evaluated using the complementary approaches of IL-1R blockade in wild-type mice in
addition to the study of renal IRI in IL-1R knockout (KO) mice. Ischemia was induced by …