Anti-inflammatory properties of estrogen: I. In vivo suppression of leukocyte production in bone marrow and redistribution of peripheral blood neutrophils
E Josefsson, A Tarkowski, H Caristen - Cellular immunology, 1992 - Elsevier
We have recently demonstrated that estrogen has differential immunomodulatory properties
in mice because it stimulates antibody responses but inhibits T cell-mediated inflammation.
In the present study we have examined the influence of estrogen on T cell-independent
inflammatory responses. A local inflammation was induced by intradermal injection of olive
oil and cholera toxin. Treatment of castrated mice with pharmacological and even
physiological doses of estradiol significantly suppressed the inflammatory response, as …
in mice because it stimulates antibody responses but inhibits T cell-mediated inflammation.
In the present study we have examined the influence of estrogen on T cell-independent
inflammatory responses. A local inflammation was induced by intradermal injection of olive
oil and cholera toxin. Treatment of castrated mice with pharmacological and even
physiological doses of estradiol significantly suppressed the inflammatory response, as …