[HTML][HTML] IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and …
J Zhao, HJ Kong, H Li, B Huang, M Yang, C Zhu… - Journal of Biological …, 2006 - ASBMB
Toll-like receptor (TLR) and interferon-γ (IFN-γ) signaling pathways are important for both
innate and adaptive immune responses. However, the cross-talk between these two
signaling pathways is incompletely understood. Here we show that IFN-γ and LPS
synergistically induce the expression of proinflammatory factors, including interleukin-1 (IL-
1), IL-6, IL-12, NO, and tumor necrosis factor-α (TNF-α). Comparable synergism was
observed between IFN-γ and peptidoglycan (PGN; a TLR2 ligand) and poly (I: C)(a TLR3 …
innate and adaptive immune responses. However, the cross-talk between these two
signaling pathways is incompletely understood. Here we show that IFN-γ and LPS
synergistically induce the expression of proinflammatory factors, including interleukin-1 (IL-
1), IL-6, IL-12, NO, and tumor necrosis factor-α (TNF-α). Comparable synergism was
observed between IFN-γ and peptidoglycan (PGN; a TLR2 ligand) and poly (I: C)(a TLR3 …