Transcriptional control of natural killer cell development and function
DGT Hesslein, LL Lanier - Advances in immunology, 2011 - Elsevier
Natural killer (NK) cells play an important role in host defense against tumors and viruses
and other infectious diseases. NK cell development is regulated by mechanisms that are
both shared with and separate from other hematopoietic cell lineages. Functionally, NK cells
use activating and inhibitory receptors to recognize both healthy and altered cells such as
transformed or infected cells. Upon activation, NK cells produce cytokines and cytotoxic
granules using mechanisms similar to other hematopoietic cell lineages especially cytotoxic …
and other infectious diseases. NK cell development is regulated by mechanisms that are
both shared with and separate from other hematopoietic cell lineages. Functionally, NK cells
use activating and inhibitory receptors to recognize both healthy and altered cells such as
transformed or infected cells. Upon activation, NK cells produce cytokines and cytotoxic
granules using mechanisms similar to other hematopoietic cell lineages especially cytotoxic …