[HTML][HTML] Altered processing of fibronectin in mice lacking heparin: a role for heparin-dependent mast cell chymase in fibronectin degradation
E Tchougounova, E Forsberg, G Angelborg… - Journal of Biological …, 2001 - ASBMB
We have previously generated a mouse strain with a defect in its heparin biosynthesis by
targeting the gene forN-deacetylase/N-sulfotransferase-2 (NDST-2). The NDST-2−/− mice
show reduced levels of various mast cell mediators such as histamine and various heparin-
binding mast cell proteases, including chymases, tryptases, and carboxypeptidase A. In this
work we have addressed the possible functional consequences of the lack of sulfated
heparin. Peritoneal cells were harvested from normal and NDST-2−/− mice. After culturing …
targeting the gene forN-deacetylase/N-sulfotransferase-2 (NDST-2). The NDST-2−/− mice
show reduced levels of various mast cell mediators such as histamine and various heparin-
binding mast cell proteases, including chymases, tryptases, and carboxypeptidase A. In this
work we have addressed the possible functional consequences of the lack of sulfated
heparin. Peritoneal cells were harvested from normal and NDST-2−/− mice. After culturing …