Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.
H Urata, A Kinoshita, KS Misono, FM Bumpus… - Journal of Biological …, 1990 - ASBMB
Although angiotensin II (Ang II)-forming enzymatic activity in the human left cardiac ventricle
is minimally inhibited by angiotensin I (Ang I) converting enzyme inhibitors, over 75% of this
activity is inhibited by serine proteinase inhibitors (Urata, H., Healy, B., Stewart, RW,
Bumpus, FM, and Husain, A.(1990) Circ. Res. 66, 883-890). We now report the identification
and characterization of the major Ang II-forming, neutral serine proteinase, from left
ventricular tissues of the human heart. A 115,150-fold purification from human cardiac …
is minimally inhibited by angiotensin I (Ang I) converting enzyme inhibitors, over 75% of this
activity is inhibited by serine proteinase inhibitors (Urata, H., Healy, B., Stewart, RW,
Bumpus, FM, and Husain, A.(1990) Circ. Res. 66, 883-890). We now report the identification
and characterization of the major Ang II-forming, neutral serine proteinase, from left
ventricular tissues of the human heart. A 115,150-fold purification from human cardiac …