Inhibition of ribosomal translocation by aminoglycoside antibiotics
MJ Cabañas, D Vázquez, J Modolell - Biochemical and biophysical …, 1978 - Elsevier
MJ Cabañas, D Vázquez, J Modolell
Biochemical and biophysical research communications, 1978•ElsevierThe translocation of AcPhe-tRNA in a purified system and that of peptidyl-tRNA in a crude,
complete polypeptide synthesizing system containing endogenous E. coli polysomes are
inhibited by antibiotics of the neomycin, kanamycin and gentamicin groups. The extent of
inhibition varies with the different antibiotics, but it correlates well with the capacity of each
antibiotic to inhibit polypeptide chain elongation. Thus, the inhibition of translocation by
these antibiotics is clearly significant for their inhibitory effect on polypeptide synthesis.
complete polypeptide synthesizing system containing endogenous E. coli polysomes are
inhibited by antibiotics of the neomycin, kanamycin and gentamicin groups. The extent of
inhibition varies with the different antibiotics, but it correlates well with the capacity of each
antibiotic to inhibit polypeptide chain elongation. Thus, the inhibition of translocation by
these antibiotics is clearly significant for their inhibitory effect on polypeptide synthesis.
The translocation of AcPhe-tRNA in a purified system and that of peptidyl-tRNA in a crude, complete polypeptide synthesizing system containing endogenous E. coli polysomes are inhibited by antibiotics of the neomycin, kanamycin and gentamicin groups. The extent of inhibition varies with the different antibiotics, but it correlates well with the capacity of each antibiotic to inhibit polypeptide chain elongation. Thus, the inhibition of translocation by these antibiotics is clearly significant for their inhibitory effect on polypeptide synthesis.
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