The intestinal stem cell
LA Chia, CJ Kuo - Progress in molecular biology and translational …, 2010 - Elsevier
The intestinal epithelium is one of the most rapidly proliferating organs in the body. A
complete turnover of the epithelium occurs every 3–5 days in the mouse, a process that is
maintained by a small population of intestinal stem cells (ISCs) that reside in the crypt bases.
The signals that regulate the behavior of these ISCs are still unknown. This has been due,
until recently, to the singular lack of definitive ISC markers. The recent identification of genes
that mark functional stem cells has yielded insights into how ISCs are regulated and …
complete turnover of the epithelium occurs every 3–5 days in the mouse, a process that is
maintained by a small population of intestinal stem cells (ISCs) that reside in the crypt bases.
The signals that regulate the behavior of these ISCs are still unknown. This has been due,
until recently, to the singular lack of definitive ISC markers. The recent identification of genes
that mark functional stem cells has yielded insights into how ISCs are regulated and …