[HTML][HTML] The mammalian gene function resource: the International Knockout Mouse Consortium

A Bradley, K Anastassiadis, A Ayadi, JF Battey… - Mammalian …, 2012 - Springer
A Bradley, K Anastassiadis, A Ayadi, JF Battey, C Bell, MC Birling, J Bottomley, SD Brown…
Mammalian genome, 2012Springer
Abstract In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious
promise to generate mutations in virtually every protein-coding gene of the mouse genome
in a concerted worldwide action. Now, 5 years later, the IKMC members have developed
high-throughput gene trapping and, in particular, gene-targeting pipelines and generated
more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700
mutant mouse strains, most of them conditional. A common IKMC web portal (www …
Abstract
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( www.knockoutmouse.org ) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
Springer