[HTML][HTML] Epithelial Cell Adhesion Molecule (EpCAM) Regulates Claudin Dynamics and Tight Junctions*♦
CJ Wu, P Mannan, M Lu, MC Udey - Journal of Biological Chemistry, 2013 - ASBMB
Epithelial cell adhesion molecule (EpCAM)(CD326) is a surface glycoprotein expressed by
invasive carcinomas and some epithelia. Herein, we report that EpCAM regulates the
composition and function of tight junctions (TJ). EpCAM accumulated on the lateral
interfaces of human colon carcinoma and normal intestinal epithelial cells but did not co-
localize with TJ. Knockdown of EpCAM in T84 and Caco-2 cells using shRNAs led to
changes in morphology and adhesiveness. TJ formed readily after EpCAM knockdown; the …
invasive carcinomas and some epithelia. Herein, we report that EpCAM regulates the
composition and function of tight junctions (TJ). EpCAM accumulated on the lateral
interfaces of human colon carcinoma and normal intestinal epithelial cells but did not co-
localize with TJ. Knockdown of EpCAM in T84 and Caco-2 cells using shRNAs led to
changes in morphology and adhesiveness. TJ formed readily after EpCAM knockdown; the …