Regulation of the intestinal epithelial barrier by the apical junctional complex
MG Laukoetter, M Bruewer… - Current opinion in …, 2006 - journals.lww.com
MG Laukoetter, M Bruewer, A Nusrat
Current opinion in gastroenterology, 2006•journals.lww.comThe epithelial apical junctional complex is important in determining epithelial barrier
properties. Recent studies have highlighted contribution of proinflammatory cytokines and
endocytosis of apical junctional complex proteins to the epithelial barrier defect. Continued
advances in understanding of this field will yield new therapeutic targets for intestinal
disorders.
properties. Recent studies have highlighted contribution of proinflammatory cytokines and
endocytosis of apical junctional complex proteins to the epithelial barrier defect. Continued
advances in understanding of this field will yield new therapeutic targets for intestinal
disorders.
Summary
The epithelial apical junctional complex is important in determining epithelial barrier properties. Recent studies have highlighted contribution of proinflammatory cytokines and endocytosis of apical junctional complex proteins to the epithelial barrier defect. Continued advances in understanding of this field will yield new therapeutic targets for intestinal disorders.
Lippincott Williams & Wilkins