Myc's broad reach

M Eilers, RN Eisenman - Genes & development, 2008 - genesdev.cshlp.org
Genes & development, 2008genesdev.cshlp.org
The role of the myc gene family in the biology of normal and cancer cells has been
intensively studied since the early 1980s. myc genes, responding to diverse external and
internal signals, express transcription factors (c-, N-, and L-Myc) that heterodimerize with
Max, bind DNA, and modulate expression of a specific set of target genes. Over the last few
years, expression profiling, genomic binding studies, and genetic analyses in mammals and
Drosophila have led to an expanded view of Myc function. This review is focused on two …
The role of the myc gene family in the biology of normal and cancer cells has been intensively studied since the early 1980s. myc genes, responding to diverse external and internal signals, express transcription factors (c-, N-, and L-Myc) that heterodimerize with Max, bind DNA, and modulate expression of a specific set of target genes. Over the last few years, expression profiling, genomic binding studies, and genetic analyses in mammals and Drosophila have led to an expanded view of Myc function. This review is focused on two major aspects of Myc: the nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology.
genesdev.cshlp.org