Membrane assembly during erythropoiesis
J Liu, N Mohandas, X An - Current opinion in hematology, 2011 - journals.lww.com
J Liu, N Mohandas, X An
Current opinion in hematology, 2011•journals.lww.comAll major red cell membrane proteins undergo dynamic changes during terminal erythroid
differentiation. Use of CD44 in conjunction with TER119 and cell size enabled the
development of a method for distinguishing distinct stages of erythroblasts during murine
erythropoiesis. These findings should enable development of detailed understanding of
membrane biogenesis during erythropoiesis and obtain mechanistic insights into disordered
erythropoiesis in various red cell disorders.
differentiation. Use of CD44 in conjunction with TER119 and cell size enabled the
development of a method for distinguishing distinct stages of erythroblasts during murine
erythropoiesis. These findings should enable development of detailed understanding of
membrane biogenesis during erythropoiesis and obtain mechanistic insights into disordered
erythropoiesis in various red cell disorders.
Summary
All major red cell membrane proteins undergo dynamic changes during terminal erythroid differentiation. Use of CD44 in conjunction with TER119 and cell size enabled the development of a method for distinguishing distinct stages of erythroblasts during murine erythropoiesis. These findings should enable development of detailed understanding of membrane biogenesis during erythropoiesis and obtain mechanistic insights into disordered erythropoiesis in various red cell disorders.
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