Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
Sphingosine 1-phosphate (S1P) is a polar sphingolipid metabolite that regulates cell
migration, differentiation, survival and complex physiological processes (Bartke and
Hannun, 2009). S1P functions primarily by activating a subgroup of the endothelial
differentiation gene (EDG) family of G-protein coupled cell surface receptors now referred to
as S1P1–5 (Lee et al., 1998; Rosen et al., 2009; Van Brocklyn et al., 1998). The biological
effects of S1P receptor signaling involve several pathways including mitogen-activated …
migration, differentiation, survival and complex physiological processes (Bartke and
Hannun, 2009). S1P functions primarily by activating a subgroup of the endothelial
differentiation gene (EDG) family of G-protein coupled cell surface receptors now referred to
as S1P1–5 (Lee et al., 1998; Rosen et al., 2009; Van Brocklyn et al., 1998). The biological
effects of S1P receptor signaling involve several pathways including mitogen-activated …