[HTML][HTML] Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida
S Tardif, MD Wilson, R Wagner, P Hunt… - Journal of Biological …, 2010 - ASBMB
Interaction of rapidly evolving molecules imparts species specificity to sperm-egg
recognition in marine invertebrates, but it is unclear whether comparable interactions occur
during fertilization in any vertebrate species. In mammals, the sperm acrosomal protein
zonadhesin is a rapidly evolving molecule with species-specific binding activity for the egg
zona pellucida (ZP). Here we show using null mice produced by targeted disruption of Zan
that zonadhesin confers species specificity to sperm-ZP adhesion. Sperm capacitation …
recognition in marine invertebrates, but it is unclear whether comparable interactions occur
during fertilization in any vertebrate species. In mammals, the sperm acrosomal protein
zonadhesin is a rapidly evolving molecule with species-specific binding activity for the egg
zona pellucida (ZP). Here we show using null mice produced by targeted disruption of Zan
that zonadhesin confers species specificity to sperm-ZP adhesion. Sperm capacitation …