[PDF][PDF] Effects of prostaglandin F2α on pituitary luteinizing hormone content of pregnant rats: a possible explanation for the luteolytic effect
AP LABHSETWAR - Reproduction, 1970 - rep.bioscientifica.com
AP LABHSETWAR
Reproduction, 1970•rep.bioscientifica.comProstaglandin F 2α induced degeneration of embryos in intact pregnant rats but not in
ovariectomized rats maintained on progesterone. The pituitary lh stores in the intact, treated
rats were significantly higher than those in the pregnant, pseudopregnant or cyclic controls.
The prostaglandin failed to inhibit the ovulatory release of lh in the cyclic rat. It is suggested
that the luteolytic effect of PGF 2α may be mediated in part by the increased synthesis and
secretion of lh.
ovariectomized rats maintained on progesterone. The pituitary lh stores in the intact, treated
rats were significantly higher than those in the pregnant, pseudopregnant or cyclic controls.
The prostaglandin failed to inhibit the ovulatory release of lh in the cyclic rat. It is suggested
that the luteolytic effect of PGF 2α may be mediated in part by the increased synthesis and
secretion of lh.
Summary
Prostaglandin F 2α induced degeneration of embryos in intact pregnant rats but not in ovariectomized rats maintained on progesterone. The pituitary lh stores in the intact, treated rats were significantly higher than those in the pregnant, pseudopregnant or cyclic controls. The prostaglandin failed to inhibit the ovulatory release of lh in the cyclic rat. It is suggested that the luteolytic effect of PGF 2α may be mediated in part by the increased synthesis and secretion of lh.
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