[HTML][HTML] μ-opioid receptor desensitization: role of receptor phosphorylation, internalization, and resensitization
Y Qiu, PY Law, HH Loh - Journal of Biological Chemistry, 2003 - ASBMB
It is generally accepted that the internalization and desensitization of μ-opioid receptor
(MOR) involves receptor phosphorylation and β-arrestin recruitment. However, a mutant
MOR, which is truncated after the amino acid residue Ser 363 (MOR363D), was found to
undergo phosphorylation-independent internalization and desensitization. As expected,
MOR363D, missing the putative agonist-induced phosphorylation sites, did not exhibit
detectable agonist-induced phosphorylation. MOR363D underwent slower internalization as …
(MOR) involves receptor phosphorylation and β-arrestin recruitment. However, a mutant
MOR, which is truncated after the amino acid residue Ser 363 (MOR363D), was found to
undergo phosphorylation-independent internalization and desensitization. As expected,
MOR363D, missing the putative agonist-induced phosphorylation sites, did not exhibit
detectable agonist-induced phosphorylation. MOR363D underwent slower internalization as …