[HTML][HTML] Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination
NM Chesarino, TM McMichael, JC Hach… - Journal of Biological …, 2014 - ASBMB
Interferon-inducible transmembrane protein 3 (IFITM3) is essential for innate defense
against influenza virus in mice and humans. IFITM3 localizes to endolysosomes where it
prevents virus fusion, although mechanisms controlling its trafficking to this cellular
compartment are not fully understood. We determined that both mouse and human IFITM3
are phosphorylated by the protein-tyrosine kinase FYN on tyrosine 20 (Tyr 20) and that
mouse IFITM3 is also phosphorylated on the non-conserved Tyr 27. Phosphorylation led to a …
against influenza virus in mice and humans. IFITM3 localizes to endolysosomes where it
prevents virus fusion, although mechanisms controlling its trafficking to this cellular
compartment are not fully understood. We determined that both mouse and human IFITM3
are phosphorylated by the protein-tyrosine kinase FYN on tyrosine 20 (Tyr 20) and that
mouse IFITM3 is also phosphorylated on the non-conserved Tyr 27. Phosphorylation led to a …