Inhibition of tumor necrosis factor reduces the severity of virus‐specific lung immunopathology

T Hussell, A Pennycook… - European journal of …, 2001 - Wiley Online Library
T Hussell, A Pennycook, PJM Openshaw
European journal of immunology, 2001Wiley Online Library
TNF antagonists are effective treatments for rheumatoid arthritis and Crohn′ s disease, and
have been tried with variable success in other diseases caused by immune damage. To test
the hypothesis that viral lung diseases caused by respiratory syncytial virus or influenza
virus are partly due to overproduction of TNF, we used anti‐TNF antibody to treat mice with
lung disease caused by these viruses. TNF depletion reduced pulmonary recruitment of
inflammatory cells, cytokine production by T cells and the severity of illness without …
Abstract
TNF antagonists are effective treatments for rheumatoid arthritis and Crohn′s disease, and have been tried with variable success in other diseases caused by immune damage. To test the hypothesis that viral lung diseases caused by respiratory syncytial virus or influenza virus are partly due to overproduction of TNF, we used anti‐TNF antibody to treat mice with lung disease caused by these viruses. TNF depletion reduced pulmonary recruitment of inflammatory cells, cytokine production by T cells and the severity of illness without preventing virus clearance. These broad beneficial effects suggest that TNF antagonists might be tested as treatments of human viral lung diseases.
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