t(3;14)(p14;q32) Results in aberrant expression of FOXP1 in a case of diffuse large B‐cell lymphoma

JAL Fenton, E Schuuring, SL Barrans… - Genes …, 2006 - Wiley Online Library
JAL Fenton, E Schuuring, SL Barrans, AH Banham, SJ Rollinson, GJ Morgan, AS Jack…
Genes, Chromosomes and Cancer, 2006Wiley Online Library
Strong expression of Forkhead box‐P1 (FOXP1), a winged‐helix transcription factor, has
been identified as an independent prognostic factor in diffuse large B‐cell lymphoma
(DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14. 1, have yet
to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin
heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric
DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of …
Abstract
Strong expression of Forkhead box‐P1 (FOXP1), a winged‐helix transcription factor, has been identified as an independent prognostic factor in diffuse large B‐cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers. © 2005 Wiley‐Liss, Inc.
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