The biology of Huntington's disease

F Saudou, S Humbert - Handbook of Clinical Neurology, 2008 - Elsevier
Publisher Summary This chapter emphasizes that Huntington's disease (HD) is a fatal
inherited neurodegenerative disorder characterized by psychiatric, cognitive, and motor
disorders and for which there is currently no effective treatment. Identification of the gene
responsible for HD has allowed a better understanding of the mechanisms responsible for
the disease. However, the exact molecular events leading to the death of the striatal neurons
are still not well understood. The huntingtin protein is expressed widely throughout the …