[HTML][HTML] A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis
M MacPherson, H San Lek, A Prescott… - Journal of Biological …, 2011 - ASBMB
The Mac-1 integrin is expressed mainly on myeloid cells and binds several ligands,
including members of the ICAM family and the complement factor iC3b. It is involved in
essential immunological processes, such as leukocyte extravasation and phagocytosis. In
addition, Mac-1 has been described to negatively regulate immune cell signaling. Recently,
a single nucleotide polymorphism conferring an amino acid change in the Mac-1 integrin
extracellular domain, R77H, was shown to be associated with systemic lupus …
including members of the ICAM family and the complement factor iC3b. It is involved in
essential immunological processes, such as leukocyte extravasation and phagocytosis. In
addition, Mac-1 has been described to negatively regulate immune cell signaling. Recently,
a single nucleotide polymorphism conferring an amino acid change in the Mac-1 integrin
extracellular domain, R77H, was shown to be associated with systemic lupus …