[HTML][HTML] Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus
WE O'Gorman, EWY Hsieh, ES Savig… - Journal of Allergy and …, 2015 - Elsevier
Background Activation of Toll-like receptors (TLRs) induces inflammatory responses
involved in immunity to pathogens and autoimmune pathogenesis, such as in patients with
systemic lupus erythematosus (SLE). Although TLRs are differentially expressed across the
immune system, a comprehensive analysis of how multiple immune cell subsets respond in
a system-wide manner has not been described. Objective We sought to characterize TLR
activation across multiple immune cell subsets and subjects, with the goal of establishing a …
involved in immunity to pathogens and autoimmune pathogenesis, such as in patients with
systemic lupus erythematosus (SLE). Although TLRs are differentially expressed across the
immune system, a comprehensive analysis of how multiple immune cell subsets respond in
a system-wide manner has not been described. Objective We sought to characterize TLR
activation across multiple immune cell subsets and subjects, with the goal of establishing a …