[HTML][HTML] A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-κB signaling
J Wu, G Lei, M Mei, Y Tang, H Li - Journal of biological chemistry, 2010 - ASBMB
C53/LZAP (also named as Cdk5rap3) is a putative tumor suppressor that plays important
roles in multiple cell signaling pathways, including DNA damage response and NF-κB
signaling. Yet how its function is regulated remains largely unclear. Here we report the
isolation and characterization of two novel C53/LZAP-interacting proteins, RCAD (Regulator
of C53/LZAP and DDRGK1) and DDRGK1 (DDRGK domain-containing protein 1). Our co-
immunoprecipitation assays confirmed their interactions, while gel filtration assay indicated …
roles in multiple cell signaling pathways, including DNA damage response and NF-κB
signaling. Yet how its function is regulated remains largely unclear. Here we report the
isolation and characterization of two novel C53/LZAP-interacting proteins, RCAD (Regulator
of C53/LZAP and DDRGK1) and DDRGK1 (DDRGK domain-containing protein 1). Our co-
immunoprecipitation assays confirmed their interactions, while gel filtration assay indicated …