[HTML][HTML] Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells
JD Davies, KLH Carpenter, IR Challis, NL Figg… - Journal of Biological …, 2005 - ASBMB
Lipid accumulation by vascular smooth muscle cells (VSMC) is a feature of atherosclerotic
plaques. In this study we describe two mechanisms whereby human VSMC foam cell
formation is driven by de novo synthesis of fatty acids leading to triacylglycerol accumulation
in intracellular vacuoles, a process distinct from serum lipoprotein uptake. VSMC cultured in
adipogenic differentiation medium accumulated lipids and were induced to express the
adipocyte marker genes adipsin, adipocyte fatty acid-binding protein, C/EBPα, PPARγ, and …
plaques. In this study we describe two mechanisms whereby human VSMC foam cell
formation is driven by de novo synthesis of fatty acids leading to triacylglycerol accumulation
in intracellular vacuoles, a process distinct from serum lipoprotein uptake. VSMC cultured in
adipogenic differentiation medium accumulated lipids and were induced to express the
adipocyte marker genes adipsin, adipocyte fatty acid-binding protein, C/EBPα, PPARγ, and …