Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains
B Kest, E Hopkins, CA Palmese, M Adler… - Pharmacology …, 2002 - Elsevier
The present study assessed the analgesic potency of morphine in 11 inbred mouse strains
before and after chronic morphine treatment. Using the 49° C tail-withdrawal test, significant
strain differences in morphine AD50 estimates derived from cumulative dose–response
curves were noted prior to tolerance induction on Day 1. AD50 estimates were reassessed
on Day 4, after three daily systemic morphine injections for 3 days using an escalating dose
schedule (10, 20, and 40 mg/kg sc). In 9 of 11 strains, morphine potency was significantly …
before and after chronic morphine treatment. Using the 49° C tail-withdrawal test, significant
strain differences in morphine AD50 estimates derived from cumulative dose–response
curves were noted prior to tolerance induction on Day 1. AD50 estimates were reassessed
on Day 4, after three daily systemic morphine injections for 3 days using an escalating dose
schedule (10, 20, and 40 mg/kg sc). In 9 of 11 strains, morphine potency was significantly …