Synaptic slaughter in Alzheimer's disease
PD Coleman, PJ Yao - Neurobiology of aging, 2003 - Elsevier
PD Coleman, PJ Yao
Neurobiology of aging, 2003•ElsevierSynaptic loss is currently established as the best neurobiological correlate of the cognitive
deficits of Alzheimer's disease (AD)[Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991)
572]. We provide evidence that still living neurons lose synapses in AD, in addition to the
synapse loss due to death of neurons. We also provide evidence indicating that in addition
to loss of synapses, synaptic function is also affected in AD by decrements in transcript
species related to synaptic vesicle trafficking.
deficits of Alzheimer's disease (AD)[Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991)
572]. We provide evidence that still living neurons lose synapses in AD, in addition to the
synapse loss due to death of neurons. We also provide evidence indicating that in addition
to loss of synapses, synaptic function is also affected in AD by decrements in transcript
species related to synaptic vesicle trafficking.
Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer’s disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking.
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