Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy

RE Study, MG Kral - Pain, 1996 - Elsevier
One of the physiological changes accompanying neuropathic pain from nerve injury is the
spontaneous firing of primary afferent fibers. At least some of this activity is thought to arise
from the dorsal root ganglion. We have investigated whether this activity is resident in the
cell bodies of dorsal root ganglion neurons and if it is retained in vitro. Dorsal root ganglion
neurons from rats with a chronic constriction injury (CCI) from 4 loose ligatures of chronic gut
sutures around the sciatic nerve were used. Isolated neurons were studied using the whole …