[HTML][HTML] Relocalizing genetic loci into specific subnuclear neighborhoods
HY Lee, KD Johnson, ME Boyer, EH Bresnick - Journal of Biological …, 2011 - ASBMB
A poorly understood problem in genetics is how the three-dimensional organization of the
nucleus contributes to establishment and maintenance of transcriptional networks. Genetic
loci can reside in chromosome" territories" and undergo dynamic changes in subnuclear
positioning. Such changes appear to be important for regulating transcription, although
many questions remain regarding how loci reversibly transit in and out of their territories and
the functional significance of subnuclear transitions. We addressed this issue using GATA-1 …
nucleus contributes to establishment and maintenance of transcriptional networks. Genetic
loci can reside in chromosome" territories" and undergo dynamic changes in subnuclear
positioning. Such changes appear to be important for regulating transcription, although
many questions remain regarding how loci reversibly transit in and out of their territories and
the functional significance of subnuclear transitions. We addressed this issue using GATA-1 …