A vector for expressing foreign genes in the brains and hearts of transgenic mice
DR Borchelt, J Davis, M Fischer, MK Lee… - Genetic analysis …, 1996 - Elsevier
An expression plasmid (MoPrP. Xho), for use in transgenic mice, was developed from the
promoter, 5′ intronic, and 3′ untranslated sequences of the murine prion protein gene.
Analyses of mice harboring the MoPrP. Xho construct with cDNA genes encoding the
amyloid precursor protein (APP) and human presenilin 1 demonstrated that this vector
provides relatively high levels of transgene-encoded polypeptides in brains and hearts of
transgenic mice. The MoPrP. Xho vector should be very useful in strategies designed to …
promoter, 5′ intronic, and 3′ untranslated sequences of the murine prion protein gene.
Analyses of mice harboring the MoPrP. Xho construct with cDNA genes encoding the
amyloid precursor protein (APP) and human presenilin 1 demonstrated that this vector
provides relatively high levels of transgene-encoded polypeptides in brains and hearts of
transgenic mice. The MoPrP. Xho vector should be very useful in strategies designed to …