Selective blockade of spontaneous motor stereotypy via intrastriatal pharmacological manipulation

MF Presti, HM Mikes, MH Lewis - Pharmacology Biochemistry and Behavior, 2003 - Elsevier
Abnormal repetitive behavior, including stereotypy, is often observed in conjunction with
developmental, neuropsychiatric, and genetic disorders. The present work employed the
deer mouse model of spontaneous and persistent stereotypy to identify basal ganglia
involvement in the mediation of these abnormal behaviors. To evaluate the hypothesis that
stereotypy is expressed in these mice due to alterations in the activity of cortico-basal
ganglia motor circuits, intrastriatal pharmacological manipulations aimed at attenuating the …