A new CD21low B cell population in the peripheral blood of patients with SLE
C Wehr, H Eibel, M Masilamani, H Illges, M Schlesier… - Clinical …, 2004 - Elsevier
A hallmark of systemic lupus erythematosus (SLE) is the production of autoantibodies.
Recent reports suggest an abnormal peripheral blood B cell homeostasis in SLE patients
without being conclusive. We analyzed by four color flow-cytometry peripheral blood B cell
subpopulations of SLE patients, healthy donors, and patients with other systemic
autoimmune diseases. IgM memory but not switched memory B cells of SLE patients were
significantly decreased compared to healthy donors, whereas transitional B cells …
Recent reports suggest an abnormal peripheral blood B cell homeostasis in SLE patients
without being conclusive. We analyzed by four color flow-cytometry peripheral blood B cell
subpopulations of SLE patients, healthy donors, and patients with other systemic
autoimmune diseases. IgM memory but not switched memory B cells of SLE patients were
significantly decreased compared to healthy donors, whereas transitional B cells …