Neutralization of MMP-2 protects Staphylococcus aureus infection induced septic arthritis in mice and regulates the levels of cytokines
S Sultana, R Adhikary, A Nandi, B Bishayi - Microbial pathogenesis, 2016 - Elsevier
Matrix metalloproteinases (MMPs) are crucial players in Staphylococcus aureus mediated
synovial tissue destruction in the pathogenesis of septic arthritis. Bacterial insult increases
proteolytic matrix fragments by activated chondrocytes and synovial fibroblasts leading to
induction of matrix metalloproteinases. Tissue destruction via MMPs induced by bacterial
products, necrotic tissues and proinflammatory cytokines have been reported. Cytokines like
TNF-α, IL-1β released from host cells in response to S. aureus infection promote cartilage …
synovial tissue destruction in the pathogenesis of septic arthritis. Bacterial insult increases
proteolytic matrix fragments by activated chondrocytes and synovial fibroblasts leading to
induction of matrix metalloproteinases. Tissue destruction via MMPs induced by bacterial
products, necrotic tissues and proinflammatory cytokines have been reported. Cytokines like
TNF-α, IL-1β released from host cells in response to S. aureus infection promote cartilage …