[HTML][HTML] Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-κB and mitogen-activated protein kinase signaling
S Wei, MWH Wang, SL Teitelbaum, FP Ross - Journal of Biological …, 2002 - ASBMB
To define the molecular mechanism (s) by which interleukin (IL)-4 reversibly inhibits
formation of osteoclasts (OCs) from bone marrow macrophages (BMMs), we examined the
capacity of this T cell-derived cytokine to impact signals known to modulate
osteoclastogenesis, which include those initiated by macrophage colony-stimulating factor
(M-CSF), receptor for activation of NF-κB ligand (RANKL), tumor necrosis factor (TNF), and
IL-1. We find that although pretreatment of BMMs with IL-4 does not alter M-CSF signaling, it …
formation of osteoclasts (OCs) from bone marrow macrophages (BMMs), we examined the
capacity of this T cell-derived cytokine to impact signals known to modulate
osteoclastogenesis, which include those initiated by macrophage colony-stimulating factor
(M-CSF), receptor for activation of NF-κB ligand (RANKL), tumor necrosis factor (TNF), and
IL-1. We find that although pretreatment of BMMs with IL-4 does not alter M-CSF signaling, it …