[HTML][HTML] A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo

SH Carroll, NA Wigner, N Kulkarni… - Journal of Biological …, 2012 - ASBMB
The differentiation of osteoblasts from their precursors, mesenchymal stem cells, is an
important component of bone homeostasis as well as fracture healing. The A2B adenosine
receptor (A2BAR) is a Gα s/α q-protein-coupled receptor that signals via cAMP. cAMP-
mediated signaling has been demonstrated to regulate the differentiation of mesenchymal
stem cells (MSCs) into various skeletal tissue lineages. Here, we studied the role of this
receptor in the differentiation of MSCs to osteoblasts. In vitro differentiation of bone marrow …