Activation of orexin signal in basal forebrain facilitates the emergence from sevoflurane anesthesia in rat
H Dong, J Niu, B Su, Z Zhu, Y Lv, Y Li, L Xiong - Neuropeptides, 2009 - Elsevier
Orexinergic system may play an important role in the regulation of anesthesia–arousal.
However, which region or which pathway mediated the effect of orexins was still unclear. In
current study, we investigated whether activation of orexin signals in basal forebrain (BF)
may alter electroencephalographic activity, induction and emergence time to sevoflurane
anesthesia in rats. Either orexin-A or orexin-B was injected into the BF while measuring
electroencephalogram (EEG) under 1.0 minimum alveolar concentration (2.4%) sevoflurane …
However, which region or which pathway mediated the effect of orexins was still unclear. In
current study, we investigated whether activation of orexin signals in basal forebrain (BF)
may alter electroencephalographic activity, induction and emergence time to sevoflurane
anesthesia in rats. Either orexin-A or orexin-B was injected into the BF while measuring
electroencephalogram (EEG) under 1.0 minimum alveolar concentration (2.4%) sevoflurane …