Sleep, anesthesiology, and the neurobiology of arousal state control

R Lydic, HA Baghdoyan - The Journal of the American Society of …, 2005 - pubs.asahq.org
Sleep, like breathing, is a biologic rhythm that is actively generated by the brain. Neuronal
networks that have evolved to regulate naturally occurring sleep preferentially modulate
traits that define states of sedation and anesthesia. Sleep is temporally organized into
distinct stages that are characterized by a unique constellation of physiologic and behavioral
traits. Sleep and anesthetic susceptibility are genetically modulated, heritable phenotypes.
This review considers 40 yr of research regarding the cellular and molecular mechanisms …