Lipid and small-molecule display by CD1 and MR1

I Van Rhijn, DI Godfrey, J Rossjohn… - Nature reviews …, 2015 - nature.com
I Van Rhijn, DI Godfrey, J Rossjohn, DB Moody
Nature reviews Immunology, 2015nature.com
The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids
and small molecules to T cells. The antigen display platforms in the four CD1 proteins are
laterally asymmetrical, so that the T cell receptor (TCR)-binding surfaces are comprised of
roofs and portals, rather than the long grooves seen in the MHC antigen-presenting
molecules. TCRs can bind CD1 proteins with left-sided or right-sided footprints, creating
unexpected modes of antigen recognition. The use of tetramers of human CD1a, CD1b …
Abstract
The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The antigen display platforms in the four CD1 proteins are laterally asymmetrical, so that the T cell receptor (TCR)-binding surfaces are comprised of roofs and portals, rather than the long grooves seen in the MHC antigen-presenting molecules. TCRs can bind CD1 proteins with left-sided or right-sided footprints, creating unexpected modes of antigen recognition. The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from those that define natural killer T cells and mucosal-associated invariant T cells.
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