[HTML][HTML] Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release
MA Gandini, A Sandoval, R González-Ramírez… - Journal of Biological …, 2011 - ASBMB
Insulin release by pancreatic β-cells is regulated by diverse intracellular signals, including
changes in Ca 2+ concentration resulting from Ca 2+ entry through voltage-gated (Ca V)
channels. It has been reported that the Rab3 effector RIM1 acts as a functional link between
neuronal Ca V channels and the machinery for exocytosis. Here, we investigated whether
RIM1 regulates recombinant and native L-type Ca V channels (that play a key role in
hormone secretion) and whether this regulation affects insulin release. Whole-cell patch …
changes in Ca 2+ concentration resulting from Ca 2+ entry through voltage-gated (Ca V)
channels. It has been reported that the Rab3 effector RIM1 acts as a functional link between
neuronal Ca V channels and the machinery for exocytosis. Here, we investigated whether
RIM1 regulates recombinant and native L-type Ca V channels (that play a key role in
hormone secretion) and whether this regulation affects insulin release. Whole-cell patch …