Antiviral activities and the mechanism of 9-beta-D-ribofuranosyl-6-alkylthiopurines on several RNA viruses from animals.

M Saneyoshi, M Hasobe… - Nucleic Acids Symposium …, 1989 - europepmc.org
M Saneyoshi, M Hasobe, K Yamamoto
Nucleic Acids Symposium Series, 1989europepmc.org
A series of 9-beta-D-ribofuranosyl-6-alkylthiopurines (6-alkyl TI) were found to inhibit in vitro
replication of infectious hematopoietic necrosis virus (IHNV), human influenza virus (IFV)
and respiratory syncytial virus (RSV) with IC50 values of about 0.06 microgram/ml, 0.7-1.5
micrograms/ml and 1-3 micrograms/ml, respectively. Viral RNA synthesis in infected cells in
the presence of actinomycin D was inhibited by treatment with the compounds dose-
dependently. It was also found that the decrease of rNTP pool size in infected cells was …
A series of 9-beta-D-ribofuranosyl-6-alkylthiopurines (6-alkyl TI) were found to inhibit in vitro replication of infectious hematopoietic necrosis virus (IHNV), human influenza virus (IFV) and respiratory syncytial virus (RSV) with IC50 values of about 0.06 microgram/ml, 0.7-1.5 micrograms/ml and 1-3 micrograms/ml, respectively. Viral RNA synthesis in infected cells in the presence of actinomycin D was inhibited by treatment with the compounds dose-dependently. It was also found that the decrease of rNTP pool size in infected cells was remarkably dose-dependent. From these findings, the mode of antiviral action of these compounds may be explained by rNTP imbalance in the treated group.
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