Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease

G Slavka, T Perkmann, H Haslacher… - … , and vascular biology, 2011 - Am Heart Assoc
G Slavka, T Perkmann, H Haslacher, S Greisenegger, C Marsik, OF Wagner, G Endler
Arteriosclerosis, thrombosis, and vascular biology, 2011Am Heart Assoc
Objective—An increased mean platelet volume (MPV), as an indicator of larger, more
reactive platelets resulting from an increased platelet turnover, may represent a risk factor for
overall vascular mortality, including myocardial infarction. We intended to identify patients at
higher risk of dying from vascular disease in a large, hospital-based cohort. Methods and
Results—A total of 206 554 first-ever admissions to the Allgemeines Krankenhaus Wien for
determination of MPV between January 1996 and July 2003 were included. Primary end …
Objective
An increased mean platelet volume (MPV), as an indicator of larger, more reactive platelets resulting from an increased platelet turnover, may represent a risk factor for overall vascular mortality, including myocardial infarction. We intended to identify patients at higher risk of dying from vascular disease in a large, hospital-based cohort.
Methods and Results
A total of 206 554 first-ever admissions to the Allgemeines Krankenhaus Wien for determination of MPV between January 1996 and July 2003 were included. Primary end points were overall vascular mortality and death due to ischemic heart disease. Multivariate Cox regression adjusted for sex, age, and platelet count was applied for analysis. MPV values were categorized into quintiles, with the lowest quintile serving as the reference category. Compared with individuals with lower MPV (<8.7 fL), hazard ratios for overall vascular mortality gradually increased to 1.5 in the highest category (≥11.01 fL). The relationship of MPV to ischemic heart disease was even stronger and increased from 1.2 (8.71 to 9.60 fL category) to 1.8 in the highest category (≥11.01 fL).
Conclusion
Our results indicate that patients with an increased MPV (≥11.01 fL) are at higher risk of death due to ischemic heart disease, with hazard ratios comparable to those reported for obesity or smoking.
Am Heart Assoc