Neural stem cells transplanted to the subretinal space of rd1 mice delay retinal degeneration by suppressing microglia activation

Z Li, Y Zeng, X Chen, Q Li, W Wu, L Xue, H Xu, ZQ Yin - Cytotherapy, 2016 - Elsevier
Background aims Retinal degeneration (RD) is an inherited eye disease characterized by
irreversible photoreceptor loss. Conventionally, the activation of the resident microglia is
secondary to the disease. Stem cell–based therapy has recently made rapid progress in
treating RD. Although it has been demonstrated that the effect of stem cell therapy may
include immunomodulation, the specific mechanisms have not been clarified. Methods
Immunocytochemistry, terminal deoxynucleotidyl transferase UTP nick end labelling …