Complement receptor 1 (CR1) and Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease and it poses an
ever-increasing burden to an aging population. Several loci responsible for the rare,
autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have
facilitated the development of the amyloid cascade hypothesis of AD aetiology. The late
onset form of the disease (LOAD) is poorly defined genetically, and up until recently the only
known risk factor was the ɛ4 allele of APOE. Recent genome-wide association studies …
ever-increasing burden to an aging population. Several loci responsible for the rare,
autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have
facilitated the development of the amyloid cascade hypothesis of AD aetiology. The late
onset form of the disease (LOAD) is poorly defined genetically, and up until recently the only
known risk factor was the ɛ4 allele of APOE. Recent genome-wide association studies …