[PDF][PDF] Catch bonds: physical models and biological functions

C Zhu, RP McEver - Molecular & Cellular Biomechanics, 2005 - cdn.techscience.cn
C Zhu, RP McEver
Molecular & Cellular Biomechanics, 2005cdn.techscience.cn
Force can shorten the lifetimes of receptorligand bonds by accelerating their dissociation.
Perhaps paradoxical at first glance, bond lifetimes can also be prolonged by force. This
counterintuitive behavior was named catch bonds, which is in contrast to the ordinary slip
bonds that describe the intuitive behavior of lifetimes being shortened by force. Fifteen years
after their theoretical proposal, catch bonds have finally been observed. In this article we
review recently published data that have demonstrated catch bonds in the selectin system …
Abstract
Force can shorten the lifetimes of receptorligand bonds by accelerating their dissociation. Perhaps paradoxical at first glance, bond lifetimes can also be prolonged by force. This counterintuitive behavior was named catch bonds, which is in contrast to the ordinary slip bonds that describe the intuitive behavior of lifetimes being shortened by force. Fifteen years after their theoretical proposal, catch bonds have finally been observed. In this article we review recently published data that have demonstrated catch bonds in the selectin system and suggested catch bonds in other systems, the theoretical models for their explanations, and their function as a mechanism for flow-enhanced adhesion.
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