Natural killer cell tolerance: licensing and other mechanisms
AH Jonsson, WM Yokoyama - Advances in immunology, 2009 - Elsevier
Armed with potent cytotoxic and immunostimulatory effector functions, natural killer (NK)
cells have the potential to cause significant damage to normal self cells unless controlled by
self‐tolerance mechanisms. NK cells identify and attack target cells based on integration of
signals from activation and inhibitory receptors, whose ligands exhibit complex expression
and/or binding patterns. Preservation of NK cell self‐tolerance must therefore go beyond
mere engagement of inhibitory receptors during effector functions. Herein, we review recent …
cells have the potential to cause significant damage to normal self cells unless controlled by
self‐tolerance mechanisms. NK cells identify and attack target cells based on integration of
signals from activation and inhibitory receptors, whose ligands exhibit complex expression
and/or binding patterns. Preservation of NK cell self‐tolerance must therefore go beyond
mere engagement of inhibitory receptors during effector functions. Herein, we review recent …