Natural killer (NK) cells potentially play a significant role in eradicating residual disease
following allogeneic haematopoietic cell transplantation, and have been explored as tools
for adoptive immunotherapy for chemotherapy-refractory patients. NK cell cytotoxicity is
modulated by multiple activating and inhibitory receptors that maintain a balance between
self-tolerance and providing surveillance against pathogens and malignant transformation.
The functional characteristics of NK cells are dictated by the strength of inhibitory receptor …