The relationship of patient age to the pathobiology of the clonal myeloid diseases
MA Lichtman, JM Rowe - Seminars in oncology, 2004 - Elsevier
The incidence of the major clonal myeloid diseases, clonal cytopenias, acute, subacute
(oligoblastic), and chronic myelogenous leukemia, polycythemia vera, thrombocythemia,
and idiopathic myelofibrosis increases in a log-linear manner from young adulthood through
advanced age. In older patients, diseases requiring cytotoxic treatment are more difficult and
less successful to manage because comorbid conditions and poor performance status are
more prevalent, decreasing the tolerance to therapy and increasing the frequency of side …
(oligoblastic), and chronic myelogenous leukemia, polycythemia vera, thrombocythemia,
and idiopathic myelofibrosis increases in a log-linear manner from young adulthood through
advanced age. In older patients, diseases requiring cytotoxic treatment are more difficult and
less successful to manage because comorbid conditions and poor performance status are
more prevalent, decreasing the tolerance to therapy and increasing the frequency of side …