Regulating billions of blood platelets: glycans and beyond
R Grozovsky, S Giannini, H Falet… - Blood, The Journal of …, 2015 - ashpublications.org
R Grozovsky, S Giannini, H Falet, KM Hoffmeister
Blood, The Journal of the American Society of Hematology, 2015•ashpublications.orgThe human body produces and removes 1011 platelets daily to maintain a normal steady
state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or
arterial occlusion and organ damage. Multifaceted and complex mechanisms control platelet
production and removal in physiological and pathological conditions. This review will focus
on different mechanisms of platelet senescence and clearance with specific emphasis on
the role of posttranslational modifications. It will also briefly address platelet transfusion and …
state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or
arterial occlusion and organ damage. Multifaceted and complex mechanisms control platelet
production and removal in physiological and pathological conditions. This review will focus
on different mechanisms of platelet senescence and clearance with specific emphasis on
the role of posttranslational modifications. It will also briefly address platelet transfusion and …
Abstract
The human body produces and removes 1011 platelets daily to maintain a normal steady state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Multifaceted and complex mechanisms control platelet production and removal in physiological and pathological conditions. This review will focus on different mechanisms of platelet senescence and clearance with specific emphasis on the role of posttranslational modifications. It will also briefly address platelet transfusion and the role of glycans in the clearance of stored platelets.
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