GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

KL Rossman, CJ Der, J Sondek - Nature reviews Molecular cell biology, 2005 - nature.com
KL Rossman, CJ Der, J Sondek
Nature reviews Molecular cell biology, 2005nature.com
Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of
Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate
numerous cellular responses such as proliferation, differentiation and movement. With 69
distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho
GTPases in humans, and they activate Rho GTPases within particular spatio-temporal
contexts. The failure to do so can have significant consequences and is reflected in the …
Abstract
Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases.
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