[HTML][HTML] A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner
C Attwooll, S Oddi, P Cartwright, E Prosperini… - Journal of biological …, 2005 - ASBMB
The transcriptional repressor E2F6 has been identified as a component of two distinct
polycomb group protein (PcG)-containing complexes, suggesting a mechanism for the
recruitment of repressive complexes to target sequences in DNA. Whereas one complex is
involved in the repression of classic E2F target genes in G 0, a role for E2F6 within the cell
cycle has yet to be defined. We searched for novel E2F6-binding proteins using a yeast two-
hybrid screen and identified the PcG protein, EPC1. We showed that, both in vitro and in …
polycomb group protein (PcG)-containing complexes, suggesting a mechanism for the
recruitment of repressive complexes to target sequences in DNA. Whereas one complex is
involved in the repression of classic E2F target genes in G 0, a role for E2F6 within the cell
cycle has yet to be defined. We searched for novel E2F6-binding proteins using a yeast two-
hybrid screen and identified the PcG protein, EPC1. We showed that, both in vitro and in …